Regenerative
Medicine &
Orthobiologics
Advanced, minimally invasive treatment strategies for joint pain, tendon injuries, ligament damage, and musculoskeletal recovery. Precision diagnostics, biologically based treatment, and individualized rehabilitation.
Treat the Injury. Support the Healing Process.
Traditional orthopedic care often relies on medication, injections to suppress inflammation, rehabilitation, or surgery. Each has an important role, but some patients may benefit from a biologically focused treatment approach.
Regenerative medicine uses biological substances and targeted procedures to influence the local environment surrounding injured tendons, ligaments, muscles, and joints.
Orthobiologic treatments such as platelet-rich plasma (PRP) use components of the patient's own blood to support natural tissue-repair signaling. Outcomes depend on the condition, treatment preparation, and patient selection.
At PRO Sports Medicine, we combine precise diagnostic assessment with targeted procedures and structured physical rehabilitation.
Our Clinical Priorities
Identify the tissue responsible for symptoms before selecting treatment.
Match the orthobiologic option to the injury and clinical evidence.
Use real-time ultrasound guidance when appropriate.
Pair procedures with progressive strengthening and mobility.
Focus on strength, activity tolerance, and sustainable recovery.
Targeted Solutions for Musculoskeletal Conditions
No single regenerative treatment is appropriate for every injury. The treatment strategy depends on tissue damage, imaging findings, previous treatment, individual health, and functional goals.
Platelet-Rich Plasma (PRP)
PRP is prepared from the patient's own blood using a centrifuge to concentrate platelets and plasma. Platelets contain growth factors and signaling proteins involved in natural tissue repair.
PRP may be considered for selected tendon conditions, chronic soft-tissue injuries, and symptomatic osteoarthritis.
PRP + Alpha-2-Macroglobulin
A2M is a naturally occurring plasma protein that acts as a protease inhibitor. Concentrated A2M may be combined with PRP as part of a treatment strategy for degenerative joint conditions.
The objective is to combine platelet signaling with additional regulation of tissue-degrading enzymes. Clinical evidence for injected A2M remains limited.
Plasma Prolotherapy
A plasma-based injection approach used in selected musculoskeletal treatment plans.
It may be incorporated into a broader rehabilitation or orthobiologic protocol, depending on the injury and clinical assessment. Evidence varies by indication.
Shockwave / EPAT Therapy
Extracorporeal shockwave therapy applies mechanical energy to targeted tissues and may be considered for certain chronic tendon and soft-tissue disorders.
It can be used independently or alongside selected injection treatments and progressive rehabilitation.
Tenex / Percutaneous Tendon Procedures
Ultrasound-guided minimally invasive procedures may be used to address certain areas of chronic abnormal tendon tissue.
These procedures are structurally directed rather than orthobiologic injections, but can fit within a comprehensive recovery strategy.
Physical Therapy & Recovery Optimization
Biological treatment alone does not replace proper rehabilitation. Progressive loading, mobility, strengthening, and biomechanical correction remain essential parts of most recovery plans.
Your rehabilitation program is adjusted to the tissue involved, symptoms, and functional progress.
From Sports Injuries to Chronic Joint Pain
Regenerative treatment may be considered for selected acute, chronic, and degenerative musculoskeletal conditions. Not every condition responds equally or is an appropriate indication for injection therapy.
Tendon Injuries
Rotator cuff tendinopathy, tennis elbow, golfer's elbow, patellar tendinopathy, Achilles tendinopathy, and plantar fascia disorders.
Joint Arthritis
Selected cases of knee, hip, shoulder, and ankle osteoarthritis, including degenerative conditions associated with chronic joint pain.
Ligament Injuries
Partial ligament injuries, chronic sprains, selected instability patterns, and soft-tissue injuries that may benefit from targeted treatment.
Shoulder Conditions
Rotator cuff tendon disease, partial tears, degenerative joint conditions, and selected chronic shoulder pain presentations.
Knee Injuries
Patellar tendon disorders, knee osteoarthritis, selected ligament injuries, and certain meniscal conditions.
Persistent Soft-Tissue Pain
Chronic overuse injuries, myotendinous disorders, scar-related symptoms, and selected sports-related soft-tissue conditions.
Advanced Musculoskeletal Ultrasound Guidance
Before treatment begins, identifying the correct pain-generating structure is essential.
Musculoskeletal ultrasound allows real-time visualization of tendons, ligaments, muscles, bursae, and selected joint structures.
During suitable procedures, ultrasound guidance helps visualize the needle, nearby structures, and precise anatomical target.
Learn About MSK UltrasoundWhy Image Guidance Matters
A Coordinated Approach From Evaluation to Recovery
Our focus is not simply performing a procedure. We aim to establish the diagnosis, select an appropriate treatment, and guide rehabilitation.
Evaluation
Review medical history, current symptoms, previous treatments, and activity goals.
Imaging & Diagnosis
Evaluate relevant findings using examination, ultrasound, or available MRI/X-ray imaging.
Targeted Treatment
Develop an individualized treatment plan based on the diagnosis and available evidence.
Rehabilitation
Progress through mobility, strengthening, activity modification, and return to desired activities.
How Orthobiologics Interact With Tissue
Orthobiologic therapies may influence cellular signaling and the environment around damaged tissue. These biological mechanisms do not necessarily translate into predictable clinical outcomes.
Growth Factor Signaling
Platelets release proteins involved in cellular communication, tissue repair, and extracellular matrix remodeling.
Collagen Remodeling
Certain biological signals may influence collagen synthesis and organization in damaged tendons and ligaments.
Inflammatory Regulation
Orthobiologic strategies may modify local inflammatory signaling in selected joint and soft-tissue conditions.
Joint Environment
Some therapies are studied for their effects on joint symptoms and local catabolic activity. Cartilage regeneration has not been established as a predictable clinical outcome.
Mechanical Loading
Appropriate rehabilitation provides mechanical stimuli necessary for building tissue tolerance and functional strength.
Individualized Recovery
Tissue quality, injury severity, nutrition, health, sleep, medication use, and rehabilitation influence recovery.
Understanding Emerging Treatment Technologies
Regenerative medicine encompasses several different treatment technologies. Their clinical evidence, indications, and regulatory status are not interchangeable.
Bone Marrow Aspirate Concentrate
BMAC is prepared from the patient's own bone marrow and contains a mixture of cells and signaling molecules.
It remains an area of ongoing study for selected orthopedic applications. BMAC should not be described as a guaranteed cartilage-regeneration or stem-cell replacement procedure.
Extracellular Vesicles & Exosomes
Extracellular vesicles are particles involved in cellular communication. Exosomes are one category being investigated in regenerative medicine.
Exosome products are not FDA-approved for orthopedic treatment. These therapies remain investigational and should not be confused with established autologous PRP procedures.
Regenerative Medicine FAQs
Common questions about treatment eligibility, recovery, safety, and expectations.
What is regenerative medicine?
How is PRP different from a cortisone injection?
Which injuries may benefit from PRP?
What is the purpose of adding A2M to PRP?
Are regenerative injections painful?
How long does recovery take?
Is regenerative medicine safe?
Will regenerative medicine prevent surgery?
Does insurance cover PRP or A2M?
How do I know which treatment is right for me?
Explore Your Options for Recovery and Performance.
Whether you're managing chronic joint pain, a tendon injury, or a sports-related condition, our team can help determine which treatment options may be appropriate.
PRO Sports Medicine
2034 E Southern Ave, Suite O
Tempe, AZ 85282
480-400-6225